The exploration of plant behavior on a cellular scale in a minimal invasive manner is key to understanding plant adaptations to their environment. Plant hormones regulate multiple aspects of growth and development and mediate environmental responses to ensure a successful life cycle. To monitor the dynamics of plant hormone actions in intact tissue, we need qualitative and quantitative tools with high temporal and spatial resolution. Here, we describe a set of biological instruments (reporters) for the analysis of the distribution and (...) signaling of various plant hormones. Furthermore, we provide examples of their utility for gaining novel insights into plant hormone action with a deeper focus on the drought hormone abscisic acid. (shrink)

Of all his contributions to philosophy it is perhaps Kant's writings on ethics that are the most widely read. Kant himself posed the famous question: What should I do? In this engaging and lucid book Julian Wuerth explores the question that frames Kant's moral philosophy and places it in a contemporary context, offering a stimulating and direct path into Kant's moral thought. He opens with a helpful introduction to the main traditions in ethics prior to Kant before outlining Kant’s (...) theory of human nature - particularly his division of the soul into the faculties of cognition, feeling and desire - which is essential for understanding his moral theory. He then introduces Kant’s arguments in his famous Groundwork of the Metaphysics of Morals , above all for his famous ‘categorical imperative’, explaining the roles of humanity, self-consciousness and freedom in Kant's moral philosophy, and Kant's identification of moral action with autonomy. The second part of the book considers criticisms of Kant’s moral philosophy, including those of Sidgwick and Hegel and asks whether Kant’s categorical imperative can provide moral guidance, before turning to the dominant, constructivist interpretations of Kant's ethics today, as defended by leading philosophers such as O’Neill and Korsgaard. Julian Wuerth argues that constructivist interpretations overlook central features of Kant's account of moral agency and so conflate the demands of virtue and happiness - in effect ascribing to Kant a view that he repeatedly targeted in previous ethical traditions. The final part of the book considers Kant’s moral philosophy from a contemporary perspective. Despite important differences between them, Kant's ethics is shown to resemble virtue ethics in addressing our development as persons, advocating a lifelong process of the cultivation of both our sensible and intellectual cognitive and emotional capacities. (shrink)

This is the first instalment of a two-part paper on the counterfactual theory of causation. It is well known that this theory is ridden with counterexamples. Specifically, the following four features of the theory suffer from problems: it understands causation as a relation between events; counterfactual dependence is understood using a metric of similarity among possible worlds; it defines a non-discriminatory concept of causation; and it understands causation as transitive. A number of philosophers have recently proposed that causation is contrastive (...) because making contrasts explicit defuses counterexamples. A contrastive causal claim has the following form: C rather than C* causes E rather than E*, where C* and E* are alternative or contrast events. In this paper, I show that making contrasts explicit does indeed defuse some counterexamples. However, I also argue that the examples discussed in the literature all share a common feature, viz. that the original causal judgement is ambiguous in one way or another. Contrasting does not help with counterexamples that do not have this feature. Part II of this paper then takes up the hard cases. (shrink)

Mandatory vaccination, including for COVID-19, can be ethically justified if the threat to public health is grave, the confidence in safety and effectiveness is high, the expected utility of mandatory vaccination is greater than the alternatives, and the penalties or costs for non-compliance are proportionate. I describe an algorithm for justified mandatory vaccination. Penalties or costs could include withholding of benefits, imposition of fines, provision of community service or loss of freedoms. I argue that under conditions of risk or perceived (...) risk of a novel vaccination, a system of payment for risk in vaccination may be superior. I defend a payment model against various objections, including that it constitutes coercion and undermines solidarity. I argue that payment can be in cash or in kind, and opportunity for altruistic vaccinations can be preserved by offering people who have been vaccinated the opportunity to donate any cash payment back to the health service. (shrink)

According to the free energy principle all living systems aim to minimise free energy in their sensory exchanges with the environment. Processes of free energy minimisation are thus ubiquitous in the biological world. Indeed it has been argued that even plants engage in free energy minimisation. Not all living things however feel alive. How then did the feeling of being alive get started? In line with the arguments of the phenomenologists, I will claim that every feeling must be felt by (...) someone. It must have mineness built into it if it is to feel a particular way. The question I take up in this paper asks how mineness might have arisen out of processes of free energy minimisation, given that many systems that keep themselves alive lack mineness. The hypothesis I develop in this paper is that the life of an organism can be seen as an inferential process. Every living system embodies a probability distribution conditioned on a model of the sensory, physiological, and morphological states that are highly probably given the life it leads and the niche it inhabits. I argue for an ecological and enactive interpretation of free energy. I show how once the life of an organism reaches a certain level of complexity mineness emerges as an intrinsic part of the process of life itself. (shrink)

This paper asks whether we should accept a weakened version of the truthmaker principle: namely, the claim that truth supervenes on being, in which 'being' is understood as whether things are. I consider a number of positive answers to this question, including the following: that the truthmaker principle is a requirement of any plausible explanation of truth; that the principle must be accepted, if we are to do justice to the Wittgensteinian insight that the world is the totality of facts, (...) not of things; and that the correctness of the principle is a necessary condition of a realist metaphysics. In my view, none of these attempts to motivate the truthmaker principle is satisfactory. (shrink)

Reasoning that compares two objects or situations to draw conclusions about previously unknown properties of one of them has traditionally been taken to be ampliative and probabilistic. I propose that it is apodeictic reasoning from a premise about isomorphic structures that is often uncertain, but which we may have good reasons to believe. I characterize the structures and their isomorphism, describe patterns of reasoning appropriate to them, and discuss some complications not immediately obvious.

Prosocial behaviour benefits another individual and occurs voluntarily. It may have a cognitive and a motivational component. The actor who benefits a recipient – for example by solving her/his problem must recognize the recipient’s goal and understand how to fulfil it and has to be motivated to support the recipient. In the current paper I will review recent studies on prosocial behavior in dogs and I will compare them to studies with primates. I will address the cognitive and motivational skills (...) required for the actor in order to support the recipient. I conclude that dogs and also chimpanzees display a number of prosocial behaviours, but there are remarkable differences. In contrast to humans, which have an outstanding biological predisposition to benefit others, dogs and chimpanzees only do so under certain conditions. (shrink)

This paper sees me clarify, elaborate, and defend the conclusions reached in my ‘Musical Works as Eternal Types’ in the wake of objections raised by Robert Howell, R. A. Sharpe, and Saam Trivedi. In particular, I claim that the thesis that musical works are discovered rather than created by their composers is obligatory once we commit ourselves to thinking of works of music as types, and once we properly understand the ontological nature of types and properties. The central argument of (...) the paper is ‘the argument from the eternal existence of properties’, its moral being that types are eternal entities because they inherit their existence conditions from their eternally existent property-associates. The two key premises in this argument—that properties exist eternally, and that a type exists just in case its property-associate exists—are motivated and then defended at length. (shrink)

I. The first proceeds from an established and assured metaphysical system. I think we may say that this theology of culture is synonymous with a Christian social philosophy, a philosophy that analyzes society and culture, and prescribes for their ills, on the basis of the truth of a metaphysical system itself independently demonstrated as to its truth and inclusiveness.

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

This paper presents arguments that challenge what I call the fact/value separability thesis: the idea, roughly, that factual judgements can be made independently of judgements of value. I will look at arguments to the effect that facts and values are entangled in the following areas of the scientific process in economics: theory development, economic concept formation, economic modelling, hypothesis testing, and hypothesis acceptance.

The main thesis of this paper is that John McDowell (in his Mind and World) tries to occupy a position that is not coherently statable; namely, that facts have objects and properties as constituents and are yet identical with true (Fregean) Thoughts. This position is contrasted with two other identity theories of truth: the robust theory, in which true propositions are identified with facts (which are understood to have objects and properties as constituents); and the modest theory, in which facts (...) are identified with true Fregean Thoughts. I argue that the modest theory is to be preferred. (shrink)

In this article, I argue that experimental ethics – like experimental economics – should also concern itself with field experiments. In particular, I defend two claims: a) that philosophers in normative ethics could considerably narrow down their disputes if they could agree on a wider range of socio-economic facts; and that b) the socio-economic facts that would be needed for this could only be generated by deliberate large-scale social experimentation. This essay normatively grounds my interest in special administration zones.

Are works of music types of performance or are they continuants? Types are unchanging entities that could not have been otherwise; continuants can undergo change through time and could have been different. Picking up on this distinction, Guy Rohrbaugh has recently argued that musical works are continuants rather than performance-types. This paper replies to his arguments and, in the course of so doing, elaborates and defends the conception of musical works as types of performance. I end the article by arguing (...) that the conception of musical works as continuants is under-motivated and, ultimately, obscure. (shrink)

The path taken by German philosophy in the twentieth century is one of the most exciting and controversial in the history of human thought, by turns radical and conservative and secular and religious. In this outstanding introduction, German Philosophy in the Twentieth Century: Dilthey to Honneth--the third and final volume in his trilogy, Julian Young examines the work of eight German philosophers and theologians of the period. He shows how they engaged with profound existential questions about individual and collective (...) lives, criticised the increasing rationalisation and mechanisation characteristic of modernity, and committed themselves to varying forms of liberalism, socialism and democracy. Young introduces and assesses the thought of the following figures: Wilhelm Dilthey, the encroachment of the natural sciences upon the study of humanity and his distinction between 'explanation' and 'understanding'; Karl Jaspers, existentialism, the challenge of nihilism and the turn to theology; Edith Stein, our understanding of other people and the philosophy of empathy from a phenomenological standpoint; Paul Tillich, philosophical theology and the 'theonomous' life; Martin Buber, Recovering the 'I-Thou' relationship in the face of modernity and religious socialism; Hans Jonas, responsibility, selfhood and threats to humanity in the twentieth century; Erich Fromm, the 'art of loving' as a bulwark against totalitarianism and the replacement of capitalism by communitarian socialism; Axel Honneth, contemporary Hegelianism and the ethics and politics of recognition. Lucidly and engagingly written, German Philosophy in the Twentieth Century: Dilthey to Honneth is essential reading for students of German philosophy, phenomenology and theology and will also be of interest to students in related fields such as literature, political theory and sociology. (shrink)

The radical view, the view we’re kind of pushing, is that the iPhone can be seen literally as a part of my mind. I actually remember things: in virtue of this information being in the iPhone, it is part of my memory. The iPhone isn’t just a tool for my cognition, it’s part of my cognition.

I discuss a puzzle that shows there is a need to develop a new metaphysical interpretation of mathematical theories, because all well-known interpretations conflict with important aspects of mathematical activities. The new interpretation, I argue, must authenticate the ontological commitments of mathematical theories without curtailing mathematicians' freedom and authority to creatively introduce mathematical ontology during mathematical problem-solving. Further, I argue that these two constraints are best met by a metaphysical interpretation of mathematics that takes mathematical entities to be constitutively constructed (...) by human activity in a manner similar to the constitutive construction of the US Supreme Court by certain legal and political activities. Finally, I outline some of the philosophical merits of metaphysical interpretations of mathematical theories of this type. (shrink)

This paper presents a new argument against the view that structural (or attitude-based) irrationality consists in failing to respond correctly to normative reasons. According to this view, a pattern of attitudes is structurally irrational if and only if that pattern guarantees that one has at least one attitude one ought not to have. I argue that this ought-violation view comes with three indispensable theoretical commitments. These commitments concern various relationships between normative permissions and oughts that govern beliefs and intentions, and (...) they may appear plausible when viewed in isolation. However, once they are collectively conjoined, they imply oughts that are incompatible with the ought-violation view of structural irrationality. In particular, on the ought-violation view, these oughts entail that you are necessarily structurally irrational whenever [you intend to p] and [you believe that it is not the case that you ought to p]. However, since you can rationally intend things that you believe to be normatively optional (e.g. merely permitted or supererogatory), the ought-violation view faces the following dilemma: it must either deny one of its essential commitments or accept as irrational a set of attitudes that are clearly not. Either way suffices to show that the ought-violation view cannot serve as a correct analysis of structural irrationality. (shrink)

Cognitive neuroscientists are currently busy searching for the neural signatures of conscious experience. I shall argue that the notion of neural correlates of consciousness employed in much of this work is subject to two very different interpretations depending on how one understands the relation between the concepts of “state consciousness” and “creature consciousness”. Localist theories treat the neural correlates of creature consciousness as a kind of background condition that must be in place in order for the brain to realise particular (...) conscious experiences. Holists on the other hand take the neural correlates of creature consciousness to be a part of the core realiser of a particular conscious experience. My aim in this paper will be threefold. First I argue we should understand creature consciousness as a property of those creatures that have a minimal sense of self. Given this conception of creature consciousness I argue that the localist position is untenable: creature consciousness cannot simply be a background condition. Finally I argue that the minimal sense of self is a consequence of the temporal structure of consciousness. It follows that any theory of NCCs must explain how experiences with a complex temporal structure can be implemented in neural processing. (shrink)

I contrast Robert Veatch's recent liberal vision of medical decision‐making with a more rationalist liberal model. According to Veatch, physicians are biased in their determination of what is in their patient's overall interests in favour of their medical interests. Because of the extent of this bias, we should abandon the practice of physicians offering what they guess to be the best treatment option. Patients should buddy up with physicians who share the same values —‘deep value pairing’. The goal of choice (...) is maximal promotion of patient values. I argue that if subjectivism about value and valuing is true, this move is plausible. However, if objectivism about value is true — that there really are states which are good for people regardless of whether they desire to be in them — then we should accept a more rationalist liberal alternative. According to this alternative, what is required to decide which course is best is rational dialogue between physicians and patients, both about the patient's circumstances and her values, and not the seeking out of people, physicians or others, who share the same values. Rational discussion requires that physicians be reasonable and empathic. I describe one possible account of a reasonable physician. (shrink)

I argue that pregnant women have a duty to refrain from behaviours or to allow certain acts to be done to them for the sake of their foetus if the foetus has a reasonable chance of living and being in a harmed state if the woman does not refrain from those behaviours or allow those things to be done to her. There is a proviso: that her refraining from acting or allowing acts to be performed upon her does not significantly (...) harm her. This duty does not presuppose that the foetus is a person. It is grounded on principles of respect for the interests of sentient beings and prevention of harm to future individuals. I give an argument for a general duty of easy rescue. (shrink)

Descriptivism in the ontology of art is the thesis that the correct ontological proposal for a kind of artwork cannot show the nascent ontological conception of such things embedded in our critical and appreciative practices to be substantially mistaken. Descriptivists believe that the kinds of revisionary art ontological proposals propounded by Nelson Goodman, Gregory Currie, Mark Sagoff, and me are methodologically misconceived. In this paper I examine the case that has been made for a local form of descriptivism in the (...) ontology of art: a form that does not quarrel with the possibility of revisionism in matters of ‘fundamental metaphysics’, but which argues that special features of the arts make descriptivism in this particular sphere obligatory. David Davies, Andrew Kania and Stephen Davies are local descriptivists in this sense. I argue that the burden of proof lies with the local descriptivist, but that this burden is too heavy for him to carry. Specifically, it emerges that the only way in which the local descriptivist can motivate his position is by arguing that our artistic practices determine the art ontological facts: a thesis that local descriptivists typically appeal to, but have not been able to argue for successfully. My conclusion is that the methodological debate in the ontology of art should now proceed by focussing on the case for global descriptivism: i.e. that form of descriptivism that opposes the possibility of revisionism in ontological matters across the board. (shrink)

Introduction -- The type/token theory introduced -- Motivating the type/token theory : repeatability -- Nominalist approaches to the ontology of music -- Musical anti-realism -- The type/token theory elaborated -- Types I : abstract, unstructured, unchanging -- Types introduced and nominalism repelled -- Types as abstracta -- Types as unstructured entities -- Types as fixed and unchanging -- Types II : platonism -- Introduction : eternal existence and timelessness -- Types and properties -- The eternal existence of properties reconsidered -- (...) Types and patterns -- Defending the type/token theory I -- Unstructuredness and analogical predication -- Musical works as fixed and unchanging -- Abstractness and audibility (again) -- Works and interpretations -- Conclusion and resumé -- Defending the type/token theory II : musical platonism -- Platonism it is : replies to Anderson and Levinson -- The existence conditions of works of music -- Composition as creative discovery -- The nature of the compositional process : replies to objections -- Composition and aesthetic appraisal : a reply to Levinson -- Composition and aesthetic appraisal : understanding, interpretation, and correctness -- Musical works as continuants : a theory rejected -- A theory introduced -- Explicating and motivating the continuant view -- The continuant view and repeatability -- Further objections to the continuant view -- Musical works as compositional actions : a critique -- Currie's action-type hypothesis -- Davies's performance theory -- Sonicism I : against instrumentalism -- Sonicism introduced -- Sonicism motivated : moderate empiricism -- Instrumentation : timbral sonicism introduced -- Scores -- Instrumentation, artistic properties, and aesthetic content -- Levinson's rejoinder -- Sonicism II : against contextualism -- Introduction : formulating contextualism -- Contextualist ontological proposals -- Levinson's doppelgänger thought-experiments -- Artistic, representational, and object-directed expressive properties -- Aesthetic and non-object-directed expressive properties -- Conclusion : the place of context. (shrink)

An innovative program recently initiated at the University of California, Los Angeles Medical Center allows people to donate a kidney in exchange for a voucher that a loved one can redeem for a kidney if and when needed. As a relatively new practice, the ethical implications of advanced kidney donation have not yet been widely discussed. This paper reflects on some of the bioethical issues at stake in this new donation program, as well as some broader philosophical issues related to (...) the meaning and moral salience of commodification. I first consider whether the literature on commercial markets in organs––a longstanding topic of bioethical debate––can meaningfully inform ethical analysis of kidney voucher programs. Specifically, I consider whether and to what extent common objections to the exchange of kidneys for cash also apply to the exchange of kidneys for “kidney vouchers.” Second, I argue that the contrast between the ethical issues raised by these two practices highlights the need to understand commodification as existing on a continuum, with different degrees of commodification giving rise to different ethical issues. Doing so can help sharpen our understanding of commodification as a moral concept, as well as its relevance to broader debates about the moral limits of markets. (shrink)

Thought experiments are ubiquitous in science and especially prominent in domains in which experimental and observational evidence is scarce. One such domain is the causal analysis of singular events in history. A long‐standing tradition that goes back to Max Weber addresses the issue by means of ‘what‐if’ counterfactuals. In this paper I give a descriptive account of this widely used method and argue that historians following it examine difference makers rather than causes in the philosopher’s sense. While difference making is (...) neither necessary nor sufficient for causation, to establish difference makers is more consistent with the historians’ more ultimate purposes. †To contact the author, please write to: Department of Philosophy, Erasmus University, 3000 DR Rotterdam, The Netherlands; e‐mail: [email protected]. (shrink)

Let me answer by way of anecdote. I recently attended a 15th anniversary gala for FAIR, the ultra-left media watchdog group, at which Chomsky was the keynote speaker. He was introduced by the spectacle of Phil Donahue, visibly humbled after his ouster from stardom by the likes of Oprah and Springer, and clearly yearning, despite his professions of radicalism, to return to the womb of the Democratic Party. Old Phil was flung from the political mainstream, he explained, by his conversations (...) with Chomsky, which began with a single sentence, still vivid in Donahue's mind: "Never trust..." Big corporations? Exploitative capitalists? Nope: "Never trust the state!". (shrink)

ABSTRACTTaking some controversial claims philosopher Jason Brennan makes in his book Against Democracy as a starting point, this paper argues in favour of two theses: There is No Such Thing as Superior Political Judgement; There Is No Such Thing as Uncontroversial Social Scientific Knowledge. I conclude that social science experts need to be kept in check, not given more power.

One objection to embryonic stem (ES) cell research is that it ‘cannibalizes’ human beings, that is, kills some human beings to benefit others. I grant for argument’s sake that the embryo is a person. Nonetheless, killing it may be justified. I show this through the Embryonic Stem Cell Lottery. Whether killing a person is justified depends on: (1) whether innocent people at risk of being killed for ES cell research also stand to benefit from the research and (2) whether their (...) overall chances of living are higher in a world in which killing and ES cell research is conducted. I call this kind of killing ‘risk reductive.‘. (shrink)

All univocal analyses of causation face counterexamples. An attractive response to this situation is to become a pluralist about causal relationships. "Causal pluralism" is itself, however, a pluralistic notion. In this article, I argue in favor of pluralism about concepts of cause in the social sciences. The article will show that evidence for, inference from, and the purpose of causal claims are very closely linked. Key Words: causation • pluralism • evidence • methodology.

Daniel K. Finn’s Moral Agency Within Social Structures and Culture: A Primer on Critical Realism for Christian Ethics (Moral Agency for short) contributes well to the mutual enrichment of critical...

ABSTRACT It is accepted that treatment of previously competent, now incompetent patients can be limited if that is what the patient would desire, if she were now competent. Expressed past preferences or an advance directive are often taken to constitute sufficient evidence of what a patient would now desire. I distinguish between desires and rational desires. I argue that for a desire to be an expression of a person's autonomy, it must be or satisfy that person's rational desires. A person (...) rationally desires a course of action if that person desires it while being in possession of all available relevant facts, without committing relevant error of logic, and “vividly imagining” what its consequences would be like for her. I argue that some competent, expressed desires obstruct autonomy. I show that several psychological mechanisms operate to prevent a person rationally evaluating what future life in a disabled state would be like. Rational evaluation is difficult. However, treatment limitation, if it is to respect autonomy, must be in accord with a patient's rational desires, and not merely her expressed desires. I illustrate the implications of these arguments for the use of advance directives and for the treatment of competent patients. (shrink)

In this research I propose to bring to light the meaning of "Venus" in the invocation of Lucretius´s De rerum natura. This paper is divided into six parts. In the first, I give an account of the various interpretations of the invocation and I systematize them. In the second I analyze and discuss three incategorizable investigations. In the third and fourth parts I expose the epicurean concepts of pleasure and divinity respectively. In the fifth I look for the terms, by (...) way of epithets, that the poet uses to refer to the goddess, bringing to light the nuances that light up them alternately in various instances of the invocation. In the sixth, finally, I give mine interpretation of vv 44-49 explaining why they should be included in the invocation. (shrink)

In a recent paper, Robert Stecker proposes the following test for whether a value possessed by an artwork is artistic or not: ‘Does one need to understand the work to appreciate its being valuable in that way? If so, it is an artistic value. If not, it is not.’ An important question here is what Stecker means by ‘appreciation’ in this context. Stecker himself says little about this, but I offer him two accounts of the nature of appreciation, both of (...) which are suggested by remarks of his own. It turns out that Stecker’s proposed test is flawed on either understanding of ‘appreciation’. (shrink)